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www.thinkSRS.com QCM100- Quartz Crystal Microbalance Theory and Calibration This chapter provides a brief introduction to the measurement techniques and calibration procedures available to QCM100 users, and describes the most popular theoretical models used to interpret results. Background Sauerbrey1 was the first to recognize the potential usefulness of the Quartz Crystal Microbalance (QCM) technology and demonstrate the extremely sensitive nature of these piezoelectric devices towards mass changes at the surface of QCM electrodes. The results of his work are embodied in the Sauerbrey equation, which relates the mass change per unit area at the QCM electrode surface to the observed change in oscillation frequency of the crystal: f = - Cf . m (equation 1) where, f - the observed frequency change, in Hz, m - the change in mass per unit area, in g/cm2, and Cf - the sensitivity factor for the crystal used (i.e. 56.6 Hz