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Keysight MLC400B
Monolithic Laser Combiner
Laser-Based Illumination System for
Microscopy/Cell Biology
Data Sheet
Overview
Keysight Technologies, Inc. MLC400B monolithic laser combiner is a stable,
reliable, and easy-to-use laser-based illumination system that is ideally suited for
fluorescence and confocal microscopy research in cellular biology. The MLC400B
is permanently aligned before leaving the factory, and never needs realignment,
making it a reliable light source at multiple wavelengths, with minimal downtime
for maintenance. An acousto-optic tunable filter (AOTF) provides fast switching
between different combinations of wavelengths and powers. Additional laser
lines can be added to the MLC400B, as research needs change.
Stable, reliable and easy-to-use
Keysight's proprietary complex monolithic optic (CMO) technology bundles
multiple beam-combining optics into a single, permanently aligned optical
structure. The CMO design reduces the number of exposed beam-combination
surfaces that are subject to contamination and require subsequent cleaning. The
beam is delivered to the microscope by a single-mode, polarization-maintaining
fiber-coupled delivery system via a proprietary fixed mounting system that keeps
the beam-steering optics permanently aligned.
Environmental changes that commonly occur in laboratories, such as temperature,
airflow, and bench top vibration, do not affect the MLC400B. The beam-combining
and beam-steering optics in the MLC400B are fully integrated with the beam
delivery architecture to ensure stable, reliable power, day-after-day.
Dual-port output
The MLC400B can be configured with an optional dual-port output for switching
between different microscope systems or switching between different illumination
paths on the same microscope system. The dual-port option enables experiments
such as TIRF/FRAP where continuous switching is required. This dual-port option
allows the laser output to be switched from one fiber to another with a rise time of
less than 1 ms at a frequency of up to 30 Hz. The switching mechanism in the dual-
port option is incorporated into the same alignment-free optical assembly as in the
standard beam combiner.
Super resolution imaging
The MLC400B can also be configured for super resolution imaging applications. A
selection of extra-high-power laser wavelengths